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2026

10-30

样本量设计手册导航（Sample Sizes for Clinical, Laboratory and Epidemiology Studies，21 章） 6 min

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adaptive-design agreement aipe alpha-spending art AUC audit Bayesian bias-variance binary-outcome bioequivalence biostatistics CI-width citation classic-chinese clinical-prediction clinical-research clinical-trials cluster-randomized confidence-interval continuous-outcome cooking correlation crossover data-science DEFF design design-effect development diagnostic-accuracy dose-finding EPV equivalence factorial feasibility Fleming-Harrington genomic-targets group-sequential handbook ICC immuno-oncology immunotherapy islr kappa likelihood-ratio literature machine-learning margin McNemar navigation negative-binomial non-inferiority non-proportional-hazards one-sided ordered-categorical overfitting p-value paired-design phase-II pilot-study pmsampsize poisson pork precision prediction-model prediction-models prevalence public-health R package rate-outcome reading-note recipe reliability repeated-measures Riley rmst ROC sample-size sensitivity-specificity sequential-design shrinkage Simon-design statistics stepped-wedge survey-sampling survival survival-analysis verification weighted-log-rank wilcoxon 吐槽

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adaptive-design adaptive-design agreement agreement aipe aipe alpha-spending alpha-spending art art AUC AUC audit audit Bayesian Bayesian bias-variance bias-variance binary-outcome binary-outcome bioequivalence bioequivalence biostatistics biostatistics CI-width CI-width citation citation classic-chinese classic-chinese clinical-prediction clinical-prediction clinical-research clinical-research clinical-trials clinical-trials cluster-randomized cluster-randomized confidence-interval confidence-interval continuous-outcome continuous-outcome cooking cooking correlation correlation crossover crossover data-science data-science DEFF DEFF design design design-effect design-effect development development diagnostic-accuracy diagnostic-accuracy dose-finding dose-finding EPV EPV equivalence equivalence factorial factorial feasibility feasibility Fleming-Harrington Fleming-Harrington genomic-targets genomic-targets group-sequential group-sequential handbook handbook ICC ICC immuno-oncology immuno-oncology immunotherapy immunotherapy islr islr kappa kappa likelihood-ratio likelihood-ratio literature literature machine-learning machine-learning margin margin McNemar McNemar navigation navigation negative-binomial negative-binomial non-inferiority non-inferiority non-proportional-hazards non-proportional-hazards one-sided one-sided ordered-categorical ordered-categorical overfitting overfitting p-value p-value paired-design paired-design phase-II phase-II pilot-study pilot-study pmsampsize pmsampsize poisson poisson pork pork precision precision prediction-model prediction-model prediction-models prediction-models prevalence prevalence public-health public-health R package R package rate-outcome rate-outcome reading-note reading-note recipe recipe reliability reliability repeated-measures repeated-measures Riley Riley rmst rmst ROC ROC sample-size sample-size sensitivity-specificity sensitivity-specificity sequential-design sequential-design shrinkage shrinkage Simon-design Simon-design statistics statistics stepped-wedge stepped-wedge survey-sampling survey-sampling survival survival survival-analysis survival-analysis verification verification weighted-log-rank weighted-log-rank wilcoxon wilcoxon 吐槽吐槽

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