Product Manager
Clinical Research · Scientific Collaboration · Molecular Diagnostics
hi@portos.wang · ORCID · Google Scholar
Profile
I began in biochemistry and molecular biology research before moving into biotechnology, where I now work across medical products, research projects, and clinical studies. My work connects experimental design, molecular diagnostics, data analysis, scientific writing, and project delivery—turning research questions into plans that can be communicated, executed, and evaluated.
My current focus is gynecologic oncology and molecular diagnostics, especially cervical cancer, endometrial cancer, and DNA methylation testing. I also support clinical research, medical reporting, grant applications, scientific publications, and research collaborations.
Career
2023—Present · Beijing Qiyuan Juhe Biotechnology Co., Ltd.（CISPOLY）
Product Manager
- Lead academic promotion, technical support, and pre- and post-sales support across regions in China.
- Connect experts and research partners; contribute to project design, scientific writing, research collaboration, and academic conference support.
- Support research project and planning management, data analysis, clinical reports, grant applications, and scientific publications.
- Work around gynecologic oncology molecular diagnostics and DNA methylation testing to support clinical translation and evidence building.
2021—2022 · Beijing Abiochem Biotechnology Co., Ltd.
Technical Support
- Provided pre- and post-sales technical support for research products and helped design research plans and product solutions.
- Supported the design, budgeting, management, and completion of preclinical drug research and animal-study projects.
- Led technical communication and application support for primary-cell and related products; commercial sales results are not disclosed.
Selected Projects
Late 2022—Late 2023 · Multicenter study of cervical cytology DNA methylation for endometrial cancer screening
Study description
A clinical diagnostic study evaluating an IVD method for the early screening and diagnosis of endometrial cancer.
Responsibilities
Managed hospital ethics materials, data management, end-user coordination, scientific research project management, center expansion, and scientific writing support.
Early 2023—Late 2025 · Multicenter clinical study of cell-free DNA methylation for ovarian cancer diagnosis and monitoring
Study description
A clinical diagnostic study evaluating an IVD method for the early screening and diagnosis of ovarian cancer.
Responsibilities
Managed hospital ethics materials, data management, end-user coordination, scientific research project management, center expansion, and scientific writing support.
Academic Projects
2018—2020 · Effects of Sini Decoction on AOM-DSS Induced Colorectal Cancer and Gut Microbiota in Mice
Study description
Part of a subproject of the National Natural Science Foundation of China ("Prevention, Control, and Regulation Techniques for Key Pet Nutritional Metabolic Diseases"), investigating the intervention efficacy, epithelial barrier protection, and gut microbiota regulation of Sini Decoction against colorectal carcinogenesis.
Responsibilities
- Co-developed experimental designs and study execution, contributing to published research in Frontiers in Pharmacology.
- Established a murine multi-cycle colitis-associated colorectal cancer (CAC) model induced by AOM-DSS.
- Evaluated tumor markers (COX-2), inflammatory cytokines (TNF-α), immune cell infiltration (CD4⁺ T cells), and intestinal tight-junction proteins using ELISA, RT-qPCR, HE staining, and immunohistochemistry.
- Analyzed fecal 16S rRNA sequencing data to elucidate gut microbiome remodeling and anti-tumor mechanisms.
2019—2020 · Roles and Mechanisms of Sini Decoction in Ulcerative Colitis Based on Gut Microbiota Dysbiosis
Study description
Supported by the National Natural Science Foundation of China (Regional Fund), focusing on gut dysbiosis in ulcerative colitis pathogenesis and evaluating mucosal barrier repair and anti-inflammatory molecular networks.
Responsibilities
- Independently conducted experimental workflows, multi-omics data integration, and manuscript drafting.
- Established a murine chronic DSS-induced ulcerative colitis model across multiple cycles.
- Measured inflammatory mediators (TNF-α), immune cell distribution, apoptotic markers, and tight-junction proteins via Western blot, ELISA, RT-qPCR, HE staining, and immunohistochemistry.
- Integrated 16S rRNA sequencing, metagenomics, and colon transcriptomic RNA-seq to investigate the interplay between microbial metabolic shifts and host gene expression.
2019—2020 · Roles and Mechanisms of Staphylococcal Enterotoxin SEC2 Mutant 2M-118 in Murine Colorectal Cancer
Study description
Supported by the National Natural Science Foundation of China (Regional Fund; core master's thesis research), evaluating the anti-tumor activity, anti-inflammatory mechanisms, and immune regulation of the engineered superantigen mutant 2M-118 in colorectal cancer.
Responsibilities
- Independently led animal experiments, molecular validations, and master's thesis preparation.
- Established AOM-DSS colorectal cancer models and administered experimental therapeutic regimens.
- Utilized flow cytometry, immunohistochemistry, ELISA, and Western blot to profile systemic and mucosal immune cell subsets (e.g., CD4⁺ T cells) and cytokine dynamics.
- Screened key targets via colon RNA-seq transcriptomics and validated TLRs/MyD88/NF-κB pathways via RT-qPCR and Western blot to uncover mechanisms governing inflammation-to-cancer transformation.
2016—2019 · Optimization of Deer Hide Gelatin Preparation and Its Immunomodulatory Mechanisms
Study description
Investigated the preparation optimization of traditional animal-derived gelatin and evaluated its hematopoietic and immunomodulatory mechanisms in blood-deficiency mouse models.
Responsibilities
- Led mechanism studies in blood-deficiency mouse models.
- Established blood-deficiency animal models and conducted complete blood counts (CBC).
- Performed primary splenocyte proliferation assays and peritoneal macrophage neutral red phagocytosis assays.
- Analyzed peripheral blood mononuclear cell (PBMC) immune subsets via flow cytometry to assess non-specific and cellular immune modulation.
2019—2020 · Roles and Mechanisms of the Exosomal ESCRT Pathway in Persistent BVDV Infection
Study description
Supported by the National Natural Science Foundation of China (Grant 3197190308), exploring ESCRT pathway regulation in persistent bovine viral diarrhea virus (BVDV) infection.
Responsibilities
- Provided technical support for virology workflows.
- Managed mouse immunization protocols, antiserum titer monitoring, and animal handling standards for BVDV monoclonal antibody generation.
Education
2018—2021 · Jilin University, College of Animal Science
M.Sc. in Biochemistry and Molecular Biology. Graduate research focused on engineered superantigens, gut microbiota, colorectal cancer, and inflammation-related mechanisms.
2014—2018 · Jilin University, College of Animal Science
B.Sc. in Biotechnology.
May—September 2020 · Hainan Tropical Ocean University
Exchange study.
Focus
- Molecular Diagnostics · Gynecologic oncology, DNA methylation, cervical and endometrial cancer screening
- Clinical Research · Clinical study projects, medical reports, and research collaboration
- Biomedical Research · Gut microbiota, inflammation, colorectal cancer, and immunomodulation
- Scientific Translation · Connecting research questions with products, projects, and clinical evidence
Capabilities
- Biomedical research planning · Frame research questions, technical routes, experiments, and clinical study plans.
- Molecular diagnostics and DNA methylation · Work with molecular biomarkers and evidence for gynecologic oncology applications.
- Clinical research and reporting · Support project delivery, data analysis, clinical reports, and research communication.
- Data analysis · Use R and related tools to organize and analyze research data.
- Grant and scientific publication support · Contribute to grant applications, manuscripts, and submission support.
- Medical product academic promotion and technical support · Connect products, research settings, and user needs.
- Expert liaison, research collaboration, and academic conferences · Support academic exchange, partnership projects, and conference activities.
- Website and WeChat Official Account development & maintenance · Develop and maintain company websites and WeChat Official Accounts.
Publications
Featured outputs
- 2027 · Endometrial cancer · Triage testing Zhang S, Wang Y, Lin J, Wu S, Liu L, Yang N, et al. Diagnostic and triage performance of CDO1 and CELF4 methylation in cervical exfoliated cells compared with serum biomarkers for endometrial cancer in abnormal bleeding women. J Gynecol Oncol. DOI
- 2026 · Cervical cancer · Risk stratification Li M, Zhang W, Wang Y, Zhao Y, Ren L, Zhao C, et al. Is Endocervical Curettage (ECC) Necessary for All HPV16/18-Positive Patients? A Stratified Analysis of 670 Cases. Pathogens. DOI
- 2026 · Cervical cancer · DNA methylation Li M, Zhang X, Zhao X, Wang J, Zhao C, Zhao Y, et al. Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma? Clin Epigenet. DOI
- 2026 · Endometrial cancer · Clinical diagnostics He P, Wang Y, Xie N, Liu C, Liu P, Wang L, et al. Diagnostic Accuracy and Concordance of Self-Collected Cervical CDO1 and CELF4 Methylation Testing Compared With Physician Sampling for Endometrial Cancer Detection. JCO Precis Oncol. DOI
- 2026 · Endometrial cancer · Clinical validation Cai B, Wang Y, Ma W, Wu Z, Yao T, Liu P, et al. Validation of a cervical CDO1/CELF4 methylation test for endometrial cancer: a prospective paired-sample comparison with intrauterine specimen. Front Med. DOI
- 2024 · Cervical cancer · Triage testing Liang H, Liu Y, Yin S, Jiang M, Dou Q, Wang H, et al. Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China. Front Oncol. DOI
- 2024 · Endometrial cancer · Prospective study Cai B, Du J, Wang Y, Liu Z, Wang Y, Li L, et al. The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China. Cytojournal. DOI
View all 22 academic and research outputs
- 2027 · Endometrial cancer · Triage testing — Zhang S, Wang Y, Lin J, Wu S, Liu L, Yang N, et al. Diagnostic and triage performance of CDO1 and CELF4 methylation in cervical exfoliated cells compared with serum biomarkers for endometrial cancer in abnormal bleeding women. J Gynecol Oncol. DOI
- 2026 · Cervical cancer · Risk stratification — Li M, Zhang W, Wang Y, Zhao Y, Ren L, Zhao C, et al. Is Endocervical Curettage (ECC) Necessary for All HPV16/18-Positive Patients? A Stratified Analysis of 670 Cases. Pathogens. DOI
- 2026 · Cervical cancer · DNA methylation — Li M, Zhang X, Zhao X, Wang J, Zhao C, Zhao Y, et al. Preliminary study on PAX1/JAM3 methylation and HPV viral load in CIN3-like squamous cell carcinoma: Are there differences from CIN3 and early invasive carcinoma? Clin Epigenet. DOI
- 2026 · Endometrial cancer · Clinical diagnostics — He P, Wang Y, Xie N, Liu C, Liu P, Wang L, et al. Diagnostic Accuracy and Concordance of Self-Collected Cervical CDO1 and CELF4 Methylation Testing Compared With Physician Sampling for Endometrial Cancer Detection. JCO Precis Oncol. DOI
- 2026 · Endometrial cancer · Clinical validation — Cai B, Wang Y, Ma W, Wu Z, Yao T, Liu P, et al. Validation of a cervical CDO1/CELF4 methylation test for endometrial cancer: a prospective paired-sample comparison with intrauterine specimen. Front Med. DOI
- 2024 · Cervical cancer · Triage testing — Liang H, Liu Y, Yin S, Jiang M, Dou Q, Wang H, et al. Assessment of PAX1 and JAM3 methylation triage efficacy across HPV genotypes and age groups in high-risk HPV-positive women in China. Front Oncol. DOI
- 2024 · Endometrial cancer · Prospective study — Cai B, Du J, Wang Y, Liu Z, Wang Y, Li L, et al. The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China. Cytojournal. DOI
- 2024 · Cervical cancer · Screening — Li L, Wang Y, Zhou J, Shou H, Liou Y-L, Liu P. Evaluation of PAX1/JAM3 gene methylation detection for cervical cancer screening: A prospective multi-center study. ESMO Open. DOI
- 2024 · Endometrial cancer · Non-invasive testing — Cai B, Liou YL, Wang Y, Liu P, Lin S, Lai Q, et al. The endometrial cancer detection using non-invasive hypermethylation of CDO1 and CELF4 genes in women with postmenopausal bleeding in Northwest China. Cytojournal. DOI
- 2024 · Endometrial cancer · Clinical screening — Cai B, Li L, Liu B, Wang Y, Wang L, Lin H, et al. The application value of CDO1 and CELF4 dual-gene methylation testing in screening for endometrial cancer in women with abnormal uterine bleeding. Int J Gynecol Cancer. DOI
- 2024 · Endometrial cancer · Clinical screening — 蔡炳昕, 李浏钰, 刘博, 刘沛, 王林海, 王义山, et al. 禾蔻安双基因甲基化检测在子宫内膜癌筛查中的应用价值. 兰州大学学报（医学版）. DOI
- 2023 · Endometrial cancer · Conference abstract — Cai B, Liou YL, Wang Y, Liu P, Lin S, Lai Q. The application value of dual gene methylation detection for endometrial cancer in women with abnormal uterine bleeding. Int J Gynecol Cancer. DOI
- 2024 · Gynecologic oncology · Molecular diagnosis — Cai B. Clinical actionability of molecular diagnosis in endometrial cancer. In: Global approach in Gynecology towards women’s healthcare. Bangkok, Thailand; 2024.
- 2023 · Preclinical safety · Immunology — 潘梦, 王义山, 宋颖, 李洪义, 周锦, 艾永兴, et al. 金葡素 SEC2 改构蛋白 2M-118 对小鼠的致呕吐、致热毒性和免疫原性作用. 海南热带海洋学院学报. DOI
- 2022 · Colorectal cancer · Preclinical study — 王义山, 李洪义, 王雨纯, 潘梦, 张晓鑫, 钟小刚, et al. 金葡素 SEC2 改构蛋白 2M-118 对 AOM-DSS 诱导小鼠结肠癌的干预作用. 海南热带海洋学院学报. DOI
- 2022 · Master’s thesis · Colorectal cancer — 王义山. 超抗原金葡菌肠毒素 SEC2 改构蛋白 2M-118 对小鼠结肠肿瘤发生的干预作用. Master’s thesis. Jilin University; 2022. DOI
- 2021 · Colorectal cancer · Gut microbiota — Wang Y, Zhang X, Li J, Zhang Y, Guo Y, Chang Q, et al. Sini Decoction Ameliorates Colorectal Cancer and Modulates the Composition of Gut Microbiota in Mice. Front Pharmacol. 2021.
- 2021 · Colorectal cancer · Applied research — 宋金玥, 宋宇, 王义山, 张笑笛, 王艺惟, 李嘉玮, et al. 四逆汤在制备预防或治疗结肠癌的药物中的应用. 2021.
- 2020 · Ulcerative colitis · Inflammation — 张莲珠, 宋颖, 马军, 王艺惟, 张昱, 范雪影, et al. 四逆汤对 DSS 诱导的小鼠溃疡性结肠炎的抗炎作用. 海南热带海洋学院学报. DOI
- 2018 · Tumor immunology · Preclinical study — Zhang X, Kang Z, Li Q, Zhang J, Cheng S, Chang H, et al. Antigen-adjuvant effects of icariin in enhancing tumor-specific immunity in mastocytoma-bearing DBA/2J mice. Biomed Pharmacother. DOI
- 2018 · Veterinary nutrition · Applied research — 宋宇, 李庆杰, 申震, 黎宏宇, 康治臣, 朱超, et al. 一种具有调节宠物肠胃功能的添加剂及其制备方法和应用. 2018.
- 2018 · Ulcerative colitis · Applied research — 宋宇, 康治臣, 张莲珠, 李庆杰, 王义山, 张笑笛, et al. 四逆汤在制备预防或治疗溃疡性结肠炎药物中的应用. 2018.
Contact
If you would like to connect around research, products, clinical studies, or academic collaboration, feel free to reach out.